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Table 3 Preinjection WOMAC scores and VAS scores

From: Intraarticular leukocyte-poor platelet-rich plasma injection is more effective than intraarticular hyaluronic acid injection in the treatment of knee osteoarthritis: a systematic review and meta-analysis of 12 randomized controlled trials

Study

Preinjection WOMAC total scores

Preinjection VAS scores

LP-PRP

HA

P value

LP-PRP

HA

P value

Cerza, 2012 (Italy) [19]

79.6 ± 9.5

75.4 ± 10.7

0.025

N/A

N/A

N/A

Sánchez, 2012 (Spain) [18]

121.8 ± 44.4

(†Normalized WOMAC scale)

115.6 ± 45.1

(†Normalized WOMAC scale)

0.378

N/A

N/A

N/A

Say, 2012 (Turkey) [16]

N/A

N/A

N/A

7.3 ± 1.6

7 ± 1.3

0.234

Vaquerizo, 2013 (Spain) [21]

45.9 ± 12.7

50.8 ± 18.4

0.137

N/A

N/A

N/A

Montañez-Heredia, 2016 (Spain) [17]

N/A

N/A

N/A

N/A

N/A

N/A

Cole, 2017 (USA) [26]

7 ± 0.53

(WOMAC pain score)

7.52 ± 0.58

(WOMAC pain score)

0.0001

5.72 ± 1.43

6.29 ± 1.57

0.0619

Raeissadat, 2017 (Iran) [22]

42.9 ± 13.5

38.8 ± 12.6

0.197

7.8 ± 1.78

7.4 ± 1.48

0.316

Louis, 2018 (France) [23]

35.5 ± 15.5

32.5 ± 23.1

0.599

4.8 ± 2.3

5.0 ± 2.4

0.712

Buendía‐López, 2019 (Spain) [25]

42.57 ± 7.3

42.62 ± 7.3

0.978

6.15 ± 1.1

6.06 ± 0.9

0.72

Huang, 2019 (China) [24]

48.19 ± 4.96

47.23 ± 5.37

 > 0.05

4.57 ± 0.61

4.54 ± 0.6

0.825

Lin, 2019 (Taiwan) [20]

52.8 ± 18.1

52.7 ± 18.1

0.601

N/A

N/A

N/A

Xu, 2021 (China) [15]

N/A

N/A

N/A

N/A

N/A

N/A

  1. N/A not applicable, due to no data provided from the original research
  2. †Normalized scores for the WOMAC can range from 0 to 100 for all subscales